Elongase genes and uses thereof

Details Elongase genes and uses thereof Elongase genes and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A01H 1/00 (2006.01) A01H 5/00 (2006.01) A01K 67/027 (2006.01) A23D 9/00 (2006.01) A23K 1/16 (2006.01) A23L 1/29 (2006.01) A61K 8/36 (2006.01) A61K 8/60 (2006.01) A61K 8/64 (2006.01) A61K 31/20 (2006.01) A61K 31/202 (2006.01) A61Q 19/00 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/10 (2006.01) C12N 15/63 (2006.01) C12N 15/82 (2006.01) C12P 7/64 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2341336

The subject invention relates to the identification of four genes involved in the elongation of polyunsaturated acids (i.e., "elongases") and to uses thereof. Two of these genes are also involved in the elongation of monounsaturated fatty acids. In particular, elongase is utilized in the conversion of gamma linolenic acid (GLA) to dihomogama linolenic acid (DGLA) and in the conversion of DGLA or 20:4n-3 to eicosapentaenoic acid (EPA). DGLA may be utilized in the production of polyunsaturated fatty acids, such as arachidonic acid (AA), docosahexaenoic acid (DHA), EPA, adrenic acid, .omega.6- docosapentaenoic acid or .omega.3-docosapentaenoic acid which may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.

L'invention concerne l'identification de quatre gènes impliqués dans l'allongement des acides polyinsaturés (<= élongases >=) et l'utilisation de ces gènes. Deux de ces gènes jouent également une rôle dans l'allongement des acides gras mono-insaturés. L'élongase est en particulier utilisée dans la conversion de l'acide gammalinoléique (GLA) en acide dihomogammalinoléique (DGLA) et dans la conversion du DGLA ou 20:4n-3 en acide eicosapentanoïque (EPA). Le DGLA peut être utilisé dans la production d'acides gras polyinsaturés tels que l'acide arachidonique (AA), l'acide docosahexanoïque (DHA), l'EPA, l'acide adrénique, l'acide .omega.6-docosahexanoïque ou .omega.3-docosapentanoïque qui peuvent être ajoutés à des compositions pharmaceutiques, nutritionnelles, à des aliments pour animaux ainsi qu'à d'autres produits, par exemple des cosmétiques.

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