Embolization material

A - Human Necessities – 61 – L

Patent

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Details

A61L 31/04 (2006.01) A61K 47/30 (2006.01) A61L 24/04 (2006.01) A61L 31/14 (2006.01)

Patent

CA 2503949

A vascular embolization material to be used for embolizing a blood vessel to thereby block the blood stream. In the most desirable case, the vascular embolization material is made of a polyethylene glycol copolymer having a water-swelling ratio of 30% or more, being degradable in a phosphate-buffered physiological saline, consisting of almost spherical grains and preferably being insoluble in water and a film made of the above polymer has a tensile modulus of elasticity of 1500 MPa or less in the state of being saturated with water. This material makes it possible to surely block a target site without causing coagulation/clogging in a catheter or a blood vessel other than the desired one. Subsequently, it is degraded, thereby relieving the blocking of blood stream and the degradation components can be metabolized or discharged from the body.

L'invention concerne un matériau d'embolisation vasculaire destiné à emboliser un vaisseau sanguin dans le but de bloquer le flux sanguin. Dans les cas les plus souhaitables, le matériau d'embolisation est constitué d'un copolymère de polyéthylène glycol avec un rapport de gonflement à l'eau de 30 % ou plus, dégradable dans un milieu physiologique salin tamponné au phosphate, consistant en des grains presque sphériques et étant, de préférence, insoluble dans l'eau, et un film constitué de ce polymère possède un module d'élasticité de 15000 Mpa, ou moins, sur le point d'être saturé en eau. Ce matériau rend possible le blocage sûr d'un site cible sans provoquer de coagulation/colmatage dans un cathéter ou dans un vaisseau sanguin autre que dans celui ciblé. Ensuite, le matériau est dégradé, ce qui libère le blocage de flux sanguin et les composants de dégradation peuvent être métabolisés ou éliminés du corps.

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