Emulsion and dispersion formulations and method

Details Emulsion and dispersion formulations and method Emulsion and dispersion formulations and method

A - Human Necessities

61

K

A61K 9/10 (2006.01) A01N 25/02 (2006.01) A01N 25/04 (2006.01) A01N 49/00 (2006.01) A01N 65/00 (2006.01) A61K 9/107 (2006.01) A61K 47/14 (2006.01) A61K 47/24 (2006.01) A61K 47/48 (2006.01) A61P 1/04 (2006.01) A61P 3/02 (2006.01) A61P 31/04 (2006.01) A61P 33/10 (2006.01)

Patent

CA 2447170

The present invention provides a process of preparing an emulsion of a solubilised compound, said compound being soluble in a physiologically acceptable aqueous or nonaqueous solvent, said process comprising: (a) adding a complexing agent to at least one said solvent containing at least one said compound, the agent being capable of forming a compound: agent complex; (b) adding an emulsifier to the solvent containing the compound and the complexing agent; and (c) forming an emulsion. The present invention also provides a process of preparing a dispersion of a compound which is insoluble in a physiologically acceptable aqueous or nonaqueous solvent but only soluble in a physiologically unacceptable solvent, said process comprising: (a) adding said compound to at least one physiologically acceptable solvent; (b) adding a complexing agent to the compound plus solvent of (a); (c) further adding an emulsifier to the compound plus solvent plus complexing agent of (b); (d) forming a dispersion of said compound in said physiologically acceptable solvent.

L'invention concerne un procédé de préparation d'une émulsion d'un composé solubilisé, ce composé étant soluble dans un solvant aqueux ou non aqueux acceptable au niveau physiologique. Ce procédé consiste (a) à ajouter un agent complexant à au moins un solvant tel que mentionné ci-dessus contenant au moins un composé tel que mentionné ci-dessus, cet agent pouvant former un composé: complexe d'agent (b) à ajouter un émulsifiant au solvant contenant le composé et l'agent complexant, et (c) à former un émulsion. L'invention concerne également un procédé de préparation d'une dispersion d'un composé insoluble dans un solvant aqueux ou non aqueux acceptable au niveau physiologique, mais soluble uniquement dans un solvant non acceptable au niveau physiologique. Ce procédé consiste (a) à ajouter ce composé à au moins un solvant acceptable au niveau physiologique, (b) à ajouter un agent complexant au composé plus le solvant de (a), (c) à ajouter ultérieurement un émulsifiant au composé plus le solvant plus l'agent complexant de (b), (d) à former une dispersion de ce composé dans ce solvant acceptable au niveau physiologique.

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