C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/87 (2006.01) A61K 9/107 (2006.01) A61K 9/127 (2006.01) A61K 31/70 (2006.01) A61K 47/44 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2259179
This invention discloses emulsion formulations comprising an aqueous carrier and the following components: triglyceride, cholesterol, phospholipid, at least one charged lipid, at least one hydrophilic biologically active molecule and, optionally, cholesteryl ester, and/or apoprotein; methods of preparing these emulsions; and the use of these emulsions as vehicles for the delivery of hydrophilic biologically active molecules to cells.
L'invention concerne des formulations d'émulsions. Ces formulations comprennent un véhicule aqueux et les composants suivants: triglycéride, cholestérol, phospholipide, au moins un lipide chargé, au moins une molécule hydrophile biologiquement active, et éventuellement, un ester de cholestéryle, et/ou une apoprotéine. L'invention traite aussi de procédés pour préparer ces émulsions, et de l'utilisation de ces émulsions comme véhicules pour l'administration de molécules hydrophiles biologiquement actives à ces cellules.
Hara Toshifumi
Huang Leaf
Borden Ladner Gervais Llp
University Of Pittsburgh
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