A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/337 (2006.01) A61K 9/107 (2006.01) A61K 47/22 (2006.01)
Patent
CA 2373994
An emulsion of incorporating one or more tocols, a co-solvent and, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans by various routes is disclosed. Also included in the emulsion is PEGylated vitamin E. PEGylated .alpha.-tocopherol includes polyethylene glycol subunits attached by a succinic acid diester at the ring hydroxyl of vitamin E and serves as a primary surfactant, stabilizer and a secondary solvent in tocol emulsions.
L'invention se rapporte à une émulsion comportant un ou plusieurs tocols et un co-solvant et stabilisée par des tensioactifs biocompatibles, qui est utilisée en tant qu'excipient ou support de médicaments thérapeutiques. Cette émulsion ne contient pratiquement pas d'éthanol et elle peut être administrée à des animaux ou des humains selon différentes voies. Ladite émulsion comporte également de la vitamine E associée à du polyéthylène glycol (PEG). Le .alpha.-tocophérol associé à du PEG comporte des sous-unités de polyéthylène glycol reliées par un diester d'acide succinique au noyau hydroxyle de la vitamine E et il sert de tensioactif primaire, de stabilisateur et de solvant secondaire dans les émulsions de tocol.
Constantinides Panayiotis P.
Lambert Karel J.
Quay Steven C.
Tustian Alexander K.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Sonus Pharmaceuticals Inc.
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