Enalapril-nitroxyderivatives derivatives and related...

Details Enalapril-nitroxyderivatives derivatives and related... Enalapril-nitroxyderivatives derivatives and related...

C - Chemistry, Metallurgy

07

D

C07D 207/16 (2006.01) A61K 31/401 (2006.01) A61K 31/404 (2006.01) A61K 31/407 (2006.01) A61K 31/4164 (2006.01) A61K 31/47 (2006.01) A61K 31/551 (2006.01) A61P 9/12 (2006.01) C07D 209/42 (2006.01) C07D 209/52 (2006.01) C07D 217/26 (2006.01) C07D 233/38 (2006.01) C07D 487/04 (2006.01) C07D 495/20 (2006.01)

Patent

CA 2529478

Compounds of formula (I): A-(X1-ONO2)S wherein A is a known ACE-inhibitor such as enalapril and X1 is a spacer such as a (C1-C6)-alkylene. The complete definition of A and X1 is given in claim 1. The compounds can be used as ACE- inhibitors for the treatment of cardiovascular and renal diseases and inflammatory processes. The example of formula (1) has an improved pharmacological activity when compared with the structurally closest related prior art compound.

La présente invention concerne des composés représentés par la formule (I): A-(X¿1?-ONO¿2?)<SB>S</SB> dans cette formule A êtes un inhibiteur ACE connu tel que l'énalaprile et X¿1? est un espaceur tel que (C¿1?-C¿6?)-alkylène. La définition complète de A et de X¿1? est données dans les revendications 1. Ces composés peuvent être utilisés comme inhibiteurs ACE pour le traitement de maladies cardio-vasculaires et rénales et de processus inflammatoires. L'exemple figurant dans la formule (1) possède une activité pharmacologique améliorée comparée au composé structurellement le plus proche de la technique antérieure.

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