Enamines

Details Enamines Enamines

C - Chemistry, Metallurgy

07

D

260/325.3

C07D 207/08 (2006.01) C07D 207/09 (2006.01) C07D 211/26 (2006.01) C07D 223/04 (2006.01)

Patent

CA 1069911

ABSTRACT OF THE DISCLOSURE There is provided new enamines of the following general formula: Image in which R may be a C1-5 alkyl group or C2-5 alkenyl group containing or not containing a reactive function such as alcohol, thioalcohol, ketone, thioketone, ether or thioether; R1 may be an alkyl group with 1 to 5 carbon atoms or an alkyl carboxylate group, or an acyl group; R2 may be hydrogen or an alkyl group containing 1 to 5 carbon atoms; R3 may be alkyl group with 1 to 5 carbon atoms, or an alkyl carboxylate group; R2 and R3 may be joined together via a methylene group; and n and m may take the values 1, 2, 3, as well as their dextro- rotary and levorotary isomers, their acid addition salts, and their quaternary ammonium salts. The compounds are useful intermediate in the preparation of N-(1-ethyl-2-pyrrolidyl- methyl)-2-methoxy-5-sulphamoyl bencamide which possesses anti- emetic properties.

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