Enantiomeric cis-3-(4,6-dihydroxychroman-3-yl-methyl)benzoic...

Details Enantiomeric cis-3-(4,6-dihydroxychroman-3-yl-methyl)benzoic... Enantiomeric cis-3-(4,6-dihydroxychroman-3-yl-methyl)benzoic...

C - Chemistry, Metallurgy

07

D

C07D 311/22 (2006.01)

Patent

CA 2146005

This invention relates to enantiomerically pure cis-3-(4,6-dihydroxychroman-3-ylmethyl)benzoic acids and processes for the preparation of such compounds. The compounds are intermediates useful in the preparation of optically pure enantiomers of cis-3-(6-arylmethyloxy-4-hydroxy-chroman-3-ylmethyl)aniline sulfonamides which are useful in the treatment of asthma, arthri- tis, psoriasis, ulcers, myocardial infarction and related diseases. More particularly it relates to (3R-cis)-3-(4,6-dihydroxychroman- 3-ylmethyl)benzoic acid. It also relates to an improved process for the preparation of racemic cis-3-(4,6-dihydroxychroman- 3-ylmethyl)benzoic acid.

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