Enantiomeric compounds with antibacterial activity

Details Enantiomeric compounds with antibacterial activity Enantiomeric compounds with antibacterial activity

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/4365 (2006.01) A61K 31/4709 (2006.01) A61P 31/04 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2664588

Novel compounds in enantiomeric excess that are inhibitors of bacterial methionyl synthetase (MetRS) are disclosed. Also disclosed are methods for their preparation and their use in therapy as antibacterial agents, and in particular their use in therapy for Clostridium difficile infection.

L'invention concerne de nouveaux composés en excès énantiomère étant des inhibiteurs de la méthionyl synthétase bactérienne (MetRS). L'invention concerne également des procédés de préparation de ces composés et leur utilisation en thérapie en tant qu'agents antibactériens, notamment dans la thérapie d'infections par clostridium difficile.

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