Enantiomeric resolution

C - Chemistry – Metallurgy – 07 – C

Patent

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C07C 57/30 (2006.01) C07B 57/00 (2006.01) C07C 51/41 (2006.01) C07C 51/487 (2006.01) C07C 59/64 (2006.01) C07C 253/34 (2006.01) C07C 255/41 (2006.01) C07D 213/80 (2006.01) C07D 307/68 (2006.01) C07D 333/38 (2006.01)

Patent

CA 2146780

A process for obtaining a substantially pure enantiomer of an aryl-substituted aliphatic carboxylic acid is described. In this process, the aryl-substituted aliphatic carboxylic acid is reacted with an inorganic base in the presence of an organic base to sub- stantially enrich the precipitate in one of the enantiomers and an improved yield. Substantially pure, enantiomeric salt is separat- ed, leaving a mother liquor comprising the solvent and aryl-substituted aliphatic carboxylic acid enriched in the other enantiomer.

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