Enantiomeric resolution of...

C - Chemistry – Metallurgy – 07 – C

Patent

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C07C 49/697 (2006.01) C07B 57/00 (2006.01) C07C 45/78 (2006.01) C07C 45/79 (2006.01) C07C 45/85 (2006.01) C08B 37/16 (2006.01)

Patent

CA 2119674

There is disclosed a method of separating enantiomers of 4-(3',4'-dichlorophenyl)-3, 4-dihydro-1(2H)-naphthalenone comprising contacting the same with a homogeneous or nonhomogeneous liquid mixture of solvent and water, the mixture containing substantially pure and unsupported gamma-cyclodextrin or its derivatives. Also disclosed are methods of further enantiomerically enriching solid mixtures obtained from the enantiomer separation method and further extracting one enantiomer by solvent extraction of the solid mixtures obtained.

On divulgue une méthode de séparation des énantiomères de la 4-(3',4'-dichlorophényl)-3,4-dihydro-1(2H)-naphtalénone comprenant la mise en contact des énantiomères avec un mélange liquide homogène ou non homogène de solvant et d'eau, le mélange contenant de la gamma-cyclodextrine, ou ses dérivés, sous une forme substantiellement pure et sans support. On divulgue également des méthodes pour continuer d'enrichir, du point de vue énantiomérique, les mélanges solides obtenus à l'aide de la méthode de séparation des énantiomères et pour faire une extraction plus poussée d'un énantiomère par extraction par solvant des mélanges solides obtenus.

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