Enantiomerically pure atomoxetine and tomoxetine mandelate

Details Enantiomerically pure atomoxetine and tomoxetine mandelate Enantiomerically pure atomoxetine and tomoxetine mandelate

C - Chemistry, Metallurgy

07

C

C07C 217/48 (2006.01) C07C 213/10 (2006.01)

Patent

CA 2561386

The present invention provides enantiomerically pure (R)-(-)-tomoxetine (S)- (+)-mandelate and atomoxetine HCI. The present invention further provides enantiomerically pure (R)-(-)-tomoxetine (S)-(+)-mandelate prepared from racemic 5 tomoxetine. The present invention also provides enantiomerically pure atomoxetine HCI prepared from (R)-(-)-tomoxetine (S)-(+)-mandelate.

L'invention concerne un (R)-(-)-tomoxetine (S)-(+)-mandélate et une atomoxétine HCI énantiomériquement purs. L'invention concerne également un (R)-(-)-tomoxetine (S)-(+)-mandélate énantiomeriquement pur préparé à partir de la tomoxétine racémique. L'invention concerne enfin une atomoxétine HCI énantiomériquement pure préparée à partir d'un (R)-(-)-tomoxetine (S)-(+)-mandelate.

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