Enantiomerically pure(-)-liarozole

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 403/06 (2006.01) A61K 31/415 (2006.01) C07D 233/61 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2182581

This invention relates to the novel enantiomer- ically pure laevorotatory isomer of liarozole of for- mula (I) and the pharmaceutically acceptable acid addition salt forms thereof. These compounds are particularly useful in treating disorders which are characterized by an increased proliferation and or abnormal differentiation of normal, preneoplastic or neoplastic epithelial cells. The compounds of for- mula (I) are particularly useful in the field of oncology. Also disclosed are compositions containing said novel compounds, methods of preparing said novel compounds as well as methods of using the mentioned compounds to treat the mentioned disorders.

L'invention se rapporte à un nouvel isomère lévogyre, pur sur le plan énantiomorphe, de liarozole de la formule (I) ainsi qu'aux formes pharmacologiquement acceptables de sels d'addition acide de celui-ci. Ces composés sont particulièrement utiles dans le traitement des affections caractérisées par une prolifération accrue et/ou une différentiation anormale des cellules épithéliales normales, prénéoplasiques ou néoplasiques. Ces composés de la formule (I) sont particulièrement utiles dans le domaine de l'oncologie. L'invention se rapporte également à des compositions contenant ces nouveaux composés, aux procédés de préparation de ceux-ci ainsi qu'aux méthodes d'utilisation desdits composés dans le traitement des affections mentionnées.

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