Enantiomers of carbazole derivatives as 5-ht1-like agonists

Details Enantiomers of carbazole derivatives as 5-ht1-like agonists Enantiomers of carbazole derivatives as 5-ht1-like agonists

C - Chemistry, Metallurgy

07

D

C07D 209/88 (2006.01) A61K 31/403 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2756876

The present invention relates to the active pharmaceutical ingredient frovatriptan and pharmaceutically acceptable salts thereof. In particular, it relates to efficient processes for the preparation of frovatriptan and its synthetic intermediates, which are amenable to large scale commercial production and provide the required products with improved yield and purity.

La présente invention concerne le principe actif pharmaceutique frovatriptan et des sels pharmaceutiquement acceptables associés. En particulier, l'invention concerne des procédés efficaces pour la préparation de frovatriptan et de ses produits intermédiaires de synthèse, ces procédés s'adaptant à la production commerciale à grande échelle et permettant de fournir les produits souhaités avec un rendement et une pureté améliorés.

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