Enantiomers of unsaturated alkyllysophosphonocholines and...

C - Chemistry – Metallurgy – 07 – F

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C07F 9/22 (2006.01) C07F 9/28 (2006.01) C07F 9/40 (2006.01)

Patent

CA 2438414

Unsaturated alkyllysophosphonocholines compounds of formula (I) or (II):or pharmaceutically-acceptable salts, prodrugs or isomers thereof. The compounds of the invention have anti-neoplastic activity, and accordingly have utility in treating cancer and related diseases. The invention also provides enantiomers of these compounds, as well as synthetic methods for producing an enantiomer, substantially free of the other enantiomer. Also disclosed are pharmaceutical compositions, as well methods for treating cancer with the pharmaceutical compositions.

L'invention concerne des alkyllysophosphonocholines non saturées de formule (1) ou (II), ou des sels, des promédicaments ou des isomères pharmaceutiquement acceptables de ces dernières. Les composés de l'invention présentent une activité anti-néoplasique, et sont donc utiles dans le traitement du cancer et de maladies associées. L'invention concerne également des énantiomères de ces composés, ainsi que des procédés synthétiques de production d'un énantiomère sensiblement exempt de l'autre énantiomère. L'invention concerne également des compositions pharmaceutiques, ainsi que des méthodes de traitement du cancer à l'aide des compositions pharmaceutiques.

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