C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 311/24 (2006.01) C07D 215/48 (2006.01) C07D 311/92 (2006.01) C07D 335/06 (2006.01) C07D 335/08 (2006.01)
Patent
CA 2574363
This in rention relates to a method for separating enantiomers of a substituted 2-tr:ifluoromethyl-2H-chromene-3-carboxylic acid or ester, a substituted 2-triifluoromethyl-1,2-dihydro-quinoline-3-carboxylic acid or ester, a substituted 2-triifluoromethyl-2H-thiochromene-3-carboxylic acid or ester, a substituted 3-tri.fluoromethyl-3,4-dihydro-naphthalene-2-carboxylic acid or ester, or a pharmaceutically acceptable salt of the acids or esters, using enantioselective fractional crystallization, enantioselective high performance liquid chromatograph yy, enantioselective steady state recycling chromatography, or enantioselective multicolumn chromatography.
L'invention concerne un procédé de séparation d'énantiomères d'un acide 2-trifluorométhyl-2H-chromène-3-carboxylique substitué ou ester, d'un acide 2-trifluorométhyl-1,2-dihydroquinoline-3-carboxylique substitué ou ester, d'un acide 2-trifluorométhyl-2H-thiochromène-3-carboxylique substitué ou ester, d'un acide 3-trifluorométhyl-3,4-dihydronaphthalène-2-carboxylique substitué ou ester, ou d'un sel pharmaceutiquement acceptable de ces acides ou esters, par cristallisation fractionnelle énantiosélective, chromatographie en phase liquide haute performance énantiosélective, chromatographie de recyclage en état stationnaire ou chromatographie multicolonne énantiosélective.
Chekal Brian P.
Freund Ernst
Grill Charles Minard
Huthmann Elke
Juza Markus
Pharmacia & Upjohn Company Llc
Sim & Mcburney
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