C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 41/00 (2006.01) C12P 7/40 (2006.01)
Patent
CA 2146556
A process for enantioselectively converting an aldehyde, a bisulfite adduct of an aldehyde or a glycidate to a chiral carbox- ylic acid is disclosed. The process utilizes a microorganism or an enzyme preparation from a microorganism and is particularly useful for producing NSAIDs of the profen class from readily available precursors. Bacteria, yeasts and fungi are exemplified as capable of transforming precursors to profens.
Heefner Donald Lee
Rossi Richard Filip
Zepp Charles Melvyn
Fetherstonhaugh & Co.
Sepracor Inc.
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