Enantioselective production of chiral carboxylic acids

C - Chemistry – Metallurgy – 12 – P

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C12P 41/00 (2006.01) C12P 7/40 (2006.01)

Patent

CA 2146556

A process for enantioselectively converting an aldehyde, a bisulfite adduct of an aldehyde or a glycidate to a chiral carbox- ylic acid is disclosed. The process utilizes a microorganism or an enzyme preparation from a microorganism and is particularly useful for producing NSAIDs of the profen class from readily available precursors. Bacteria, yeasts and fungi are exemplified as capable of transforming precursors to profens.

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