Encapsulated mouse cells transformed with avian...

Details Encapsulated mouse cells transformed with avian... Encapsulated mouse cells transformed with avian...

C - Chemistry, Metallurgy

12

N

167/165, 119/75

C12N 15/18 (2006.01) A61D 19/00 (2006.01) A61K 9/00 (2006.01) A61K 38/27 (2006.01) C07K 14/61 (2006.01) C12N 11/04 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 1294879

TITLE OF THE INVENTION ENCAPSULATED MOUSE CELLS TRANSFORMED WITH AVIAN RETROVIRUS-BOVINE GROWTH HORMONE DNA, AND A METHOD OF ADMINISTERING BGH IN VIVO ABSTRACT OF THE DISCLOSURE Recombinant DNA constructs having an avian retroviral long terminal repeat (LTR) ligated to the bovine growth hormone gene, were co-transformed into a mammalian cell (mouse) culture in order to obtain a stable cell culture secreting large amounts of bovine growth hormone. The transformed mouse cells were encapsulated in hollow fibers and implanted into animals, thereby producing circulating bovine growth hormone.

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