Encapsulation of bioactive complexes in liposomes

Details Encapsulation of bioactive complexes in liposomes Encapsulation of bioactive complexes in liposomes

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 9/133 (2006.01)

Patent

CA 2362485

This invention provides a method to prepare liposome-encapsulated bioactive agents such as nucleic acids, comprising complexation of the bioactive agents in reverse micelles prior to forming liposomes, as well as methods of using the liposomes so formed and formulations to deliver nucleic acids to cells.

L'invention concerne un procédé d'élaboration d'agents bioactifs, tels des acides nucléiques, encapsulés dans des liposomes, qui comporte une étape de formation de complexes d'agents bioactifs dans des micelles inversées précédant la formation des liposomes ; et des procédés d'utilisation des liposomes ainsi formés ainsi que des formulations permettant d'administrer des acides nucléiques à des cellules.

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