C - Chemistry – Metallurgy – 08 – L
Patent
C - Chemistry, Metallurgy
08
L
C08L 5/04 (2006.01) A61K 9/00 (2006.01) A61K 35/12 (2006.01) A61L 27/20 (2006.01) A61L 27/38 (2006.01) A61L 27/54 (2006.01) C08L 77/04 (2006.01)
Patent
CA 2625875
The present invention is directed to a composition comprising high mannuronic acid-containing alginate and a polycation having a polydispersity index of less than 1.5. The composition is particularly useful for making biocompatible microcapsules containing living cells for allo- or xeno-transplantation. Such microcapsules have enhanced durability and can maintain their structural and functional integrity over long periods of time compared to prior art alginate microcapsules.
L'invention concerne une composition comprenant un alginate à teneur élevée en acide mannuronique et un polycation présentant un indice de polydispersité inférieur à 1,5. Ladite composition est particulièrement utile pour produire des microcapsules biocompatibles contenant des cellules vivantes destinées à une allotransplantation ou à une xénotransplantation. Ces microcapsules présentent une durabilité améliorée et peuvent conserver leur intégrité structurelle et fonctionnelle pendant de longues périodes par rapport aux microcapsules d'alginate de l'état de la technique.
Bintz Briannan
Emerich Dwaine
Geaney Marilyn Sandra
Skinner Stephen John Martin
Tan Paul Lip Jin
Living Cell Products Pty Limited
Smart & Biggar
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