Enclosed desorption electrospray ionization

H - Electricity – 01 – J

Patent

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Details

H01J 49/16 (2006.01)

Patent

CA 2673596

An improvement to Desorption Electrospray Ionization (DESI), the process of creating ions directly from sample surfaces for mass spectrometric (MS) analysis by impinging a liquid spray onto the surface. The improvement is brought about by enclosing the spray and sample surface and MS-inlet capillary in a pressure tight enclosure. The invention includes methods of sampling a larger or smaller area of surface by impacting and collecting droplets from such an area. The invention allows DESI to be performed without need for careful control of the geometry of the sprayer and MS-inlet capillary positions and angles relative to the sample surface.

L'invention concerne une amélioration du procédé DESI (désorption - ionisation par électrospray), le procédé de création d'ions directement à partir de surfaces d'échantillon pour analyse par spectrométrie de masse (MS) en précipitant un spray liquide sur la surface. L'amélioration est mise en AEuvre en renfermant le spray et la surface de l'échantillon et un capillaire d'entrée MS dans une enceinte étanche à la pression. L'invention comprend des procédés d'échantillonnage d'une surface plus grande ou plus petite par précipitation et recueil de gouttelettes sur cette surface. L'invention permet au procédé DESI d'être réalisé sans avoir besoin de contrôler soigneusement la géométrie du pulvérisateur et les positions du capillaire d'entrée MS et les angles par rapport à la surface de l'échantillon.

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