Endermic preparation for external application

A - Human Necessities – 61 – K

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167/310, 167/322

A61K 8/23 (2006.01) A61K 8/02 (2006.01) A61K 8/22 (2006.01) A61K 8/49 (2006.01) A61Q 19/02 (2006.01)

Patent

CA 2021861

ABSTRACT OF THE DISCLOSURE Disclosed is an endermic preparation for external application, which comprises a kojic acid or kojic acid derivatives as melanogenesis-inhibiting agents along with sodium hydrogensulfite and/or hydrogen peroxide as a discoloration-inhibiting agent. By addition of the discoloration-inhibiting agents, discoloration of kojic acid and its derivatives during storage thereof may effectively be prevented, and the high commercial value of the endermic preparation is maintained. - 21 -

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