Endocrine cell lines and method of using the same

Details Endocrine cell lines and method of using the same Endocrine cell lines and method of using the same

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2482915

It is intended to provide: (1) various cell lines originating in mammalian hypothalamus and pancreatic islet; (2) an expression cloning system of an active peptide precursor gene using such a cell line as a host and a process for producing an active peptide; (3) a method of searching for a substance acting on the cells and a method of evaluating the same with the use of the above cell line; (4) a method of searching for a useful gene or a useful peptide and a method of acquiring the same with the use of the above cell line; and (5) a highly sensitive and convenient GPCR ligand assay system to be used in the above expression cloning system.

L'invention concerne (1) diverses lignées cellulaires issues de l'hypothalamus mammalien et de l'îlot pancréatique, (2) un système de clonage d'expression d'un gène précurseur peptidique actif utilisant une lignée cellulaire de ce type comme hôte et un procédé de production d'un peptide actif, (3) un procédé de recherche d'une substance agissant sur ces cellules et un procédé d'évaluation de cette substance à l'aide de la lignée cellulaire susmentionnée, (4) un procédé de recherche d'un gène utile ou d'un peptide utile ainsi qu'un procédé d'acquisition de ces derniers à l'aide de la lignée cellulaire susmentionnée et (5) un système de dosage de ligands au GPCR, commode et hautement sensible, à utiliser dans le système de clonage d'expression susmentionné.

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