Endogenous and non-endogenous versions of human g...

Details Endogenous and non-endogenous versions of human g... Endogenous and non-endogenous versions of human g...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 45/00 (2006.01) C07K 14/705 (2006.01) C12N 15/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2390547

The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor for which the endogenous ligand is unknown ("orphan GPCR receptors"), and most particularly to mutated (non-endogenous) versions of the human GPCRs for evidence of constitutive activity.

La présente invention concerne des récepteurs transmembranaires, plus particulièrement un récepteur couplé à la protéine G humaine pour lequel le ligand endogène est inconnu (récepteurs GPCR orphelins), et plus particulièrement des versions mutées (non-endogènes) des GPCR humains de façon à mettre en évidence une activité constitutive.

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