Endogenous retrovirus up-regulated in prostate cancer

Details Endogenous retrovirus up-regulated in prostate cancer Endogenous retrovirus up-regulated in prostate cancer

C - Chemistry, Metallurgy

12

N

C12N 15/48 (2006.01) A61K 31/7088 (2006.01) A61K 38/16 (2006.01) A61K 39/21 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 31/14 (2006.01) C07H 21/00 (2006.01) C07K 14/15 (2006.01) C07K 16/10 (2006.01) C12N 1/00 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2468903

A specific member of the HERV-K family located in chromosome 22 at 20.428 megabases (22q11.2) has been found to be preferentially and significantly up- regulated in prostate tumors. The invention provides methods for diagnosing prostate cancer, comprising the step of detecting in a patient sample the presence or absence of an expression product of the virus. The virus has five features not seen in other HERV-K members: (1) its own specific nucleotide sequence, and consequently amino acid sequences; (2) tandem 5' LTRs; (3) a fragmented 3' LTR; (4) an env gene interrupted by an alu insertion; and (5) unique gag sequences.

L'invention concerne un élément spécifique de la famille de HERV-K situé dans le chromosome 22 au niveau des mégabases 20 428 (22q11.2) ayant été découvert comme étant régulé positivement de façon préférentiel et significative dans les tumeurs de la prostate. Cette invention concerne des procédés destinés à diagnostiquer le cancer de la prostate, comprenant l'étape de détection dans un échantillon d'un patient de la présence ou de l'absence d'un produit d'expression du virus. Le virus présente cinq caractéristiques qui ne se voient pas dans d'autres éléments du HERV-K : (1) sa propre séquence nucléotidique spécifique et, par conséquent, ses séquences d'acide aminé; (2) du LTR 5' en tandem; (3) du LTR 3' fragmenté; (4) un gène <i>env</i> interrompu par une insertion alu et (5) des séquences gag uniques.

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