Endometriosis mouse model

Details Endometriosis mouse model Endometriosis mouse model

A - Human Necessities

01

K

A01K 67/027 (2006.01)

Patent

CA 2284778

The invention provides an endometriosis mouse model wherein severely compromised immune deficient (SCID) female mice are transplanted with human xenografts of normal endometrial tissue, but result in mice with human endometriosis. Typically, the xenografts are treated with a micronized estrogen source prior to transplantation or implantation and the endogenous progesterone of the mice is eliminated also prior to transplantation of the human xenograft. These diseased mice are useful in the study of endometriosis.

Cette invention porte sur des souris utilisées comme modèle pour l'étude de l'endométriose. On greffe sur des souris femelles dont les défenses immunitaires sont sérieusement affaiblies (SCID) des hétérogreffes de tissu endométrial normal humain, ce qui a, néanmoins, pour effet de provoquer une endométriose de type humain chez ces souris. Les hétérogreffes sont, d'ordinaire, traitées au moyen d'une source d'oestrogène micronisé avant la greffe ou l'implantation et l'on élimine également la progestérone endogène de l'animal avant la greffe de cette hétérogreffe. Ces souris contaminées sont utiles à l'étude de l'endométriose.

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