Endonucleases

Details Endonucleases Endonucleases

C - Chemistry, Metallurgy

12

N

C12N 9/16 (2006.01) A61K 31/70 (2006.01) A61K 38/46 (2006.01) A61K 48/00 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/22 (2006.01) C12N 15/10 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2084790

This invention provides catalytic molecules capable of cleaving target nucleotide sequences. More specifically, the inven- tion provides an endonuclease of formula (I) wherein X and Y represent nucleotide sequences comprised of deoxyribonucleo- tides, ribonucleotides, or combinations thereof or derivatives thereof; said nucleotide sequences being of sufficient length to al- low hybridization to a target nucleic acid sequence desired to be cleaved by said endonuclease; and wherein M represents a catalytic region of formula (II) where, A, G, C and U respectively represent bases adenine, guanine, cytosine and uracil which may be in the form of deoxyribonucleotides, ribonucleotides, or combinations thereof or derivatives thereof; and N12 is selected from any of the bases adenine, guanine, cytosine, uracil or thymine, or derivatives thereof; and wherein P is one or more nu- cleotides, which nucleotides may be deoxyribonucleotides ribonucleotides, or a combination of one or more deoxyribonucle- otides and one or more ribonucleotides, or derivatives thereof, wherein if said nucleotides solely comprise ribonucleotides and the nucleotide sequences X and Y are solely comprised of ribonucleotides, then said ribonucleotides of the group P are not base paired to one another; or a bond or any atom or any group of interconnected atoms linking nucleotides A7 and G8, which does not destroy the cleavage capability of the catalytic region and which is not solely comprised of nucleotides.

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