Endoprosthesis with long-term stability

A - Human Necessities – 61 – L

Patent

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Details

A61L 27/26 (2006.01) A61L 27/22 (2006.01) A61L 27/34 (2006.01) A61L 27/36 (2006.01) A61L 27/48 (2006.01) A61L 27/54 (2006.01)

Patent

CA 2370685

The invention relates to the use of an active substance complex for creating biological parts, in particular organs for living organisms, with the following components which differ from one another and are specifically adapted to the respective biological part which is to be created, namely at least one structural component based on extracellular material specifically adapted to the cells of the respective biological part which is to be created, at least one recruiting component, at least one adhesion component, and at least one growth and/or maturation component for producing an endoprosthesis implant. The outer surface (I) of the endoprosthesis is coated at least partially with the active substance complex. In addition, the endoprosthesis has at least one cavity (II) which is filled with the active substance complex. In order to reduce the amount of active substance complex needed for filling the at least one cavity (II), the active substance complex can additionally be applied to a further support material such as collagen or a suitable polymer.

L'invention concerne l'utilisation d'un complexe de principes actifs pour la réalisation de parties biologiques, en particulier d'organes pour être vivants, comprenant des composants différents les uns des autres et adaptés spécifiquement à la partie biologique à réaliser, à savoir: au moins un composant structural à base d'un matériau extracellulaire adapté spécifiquement aux cellules de la partie biologique à réaliser, au moins un composant de recrutement, au moins un composant d'adhésion et au moins un composant de croissance et/ou de maturation pour la production d'un implant endoprotétique. Selon l'invention, la surface extérieure (I) de l'endoprothèse est, au moins partiellement, recouverte du complexe de principes actifs. En outre, l'endoprothèse présente au moins une cavité (II) qui est remplie dudit complexe de principes actifs.

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