Endorphins having placental or pancreatic origin

Details Endorphins having placental or pancreatic origin Endorphins having placental or pancreatic origin

A - Human Necessities

61

K

167/113

A61K 35/50 (2006.01) A61K 35/39 (2006.01) A61K 37/02 (1980.01)

Patent

CA 1177394

ABSTRACT OF THE DISCLOSURE A peptide endorphin having a molecular weight in the range of about 4500 to 5000 daltons is described. This peptide endorphin has .beta.-endorphin-like activity, reacting immunologically to rabbit antisera prepared against .beta.-endorphin and displacing Naloxone from opiate receptors in brain tissue. Unlike .beta.-endorphin, however, this peptide endorphin does not exhibit respiratory depressor effect when administered to mice. This peptide endorphin can be obtained from placental and pancreatic tissue, preferably by extracting with dilute mineral acid.

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