Endosomolytically active particles

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/87 (2006.01) A61K 47/48 (2006.01) C07K 19/00 (2006.01) C12N 7/04 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2172139

Endosomolytically active virus-like particle which is made up of units of capsid proteins of viruses or virus- like particles, the capsid protein units having a membrane-active peptide sequence. The particles are suitable as components of compositions for transporting nucleic acids into higher eukaryotic cells by receptor- mediated endocytosis.

Une particule de type viral à activité endosomolytique se compose d'unités de protéines de capside de virus ou de particules de type viral, ces unités protéiques de capside présentant une séquence peptidique à activité membranaire. Ces particules conviennent comme constituant de compositions permettant le transport d'acides nucléiques dans des cellules eucaryotes supérieures par l'intermédiaire d'endocytoses transmises par des récepteurs.

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