C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
530/13, 530/15.0
C12N 15/62 (2006.01) A61K 47/48 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 1/00 (2006.01) C12N 5/10 (2006.01) C12N 9/78 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01) C12P 21/00 (2006.01) C12P 21/08 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2031518
DNA sequences encoding endothelial calf-leukocyte adhesion molecules ELAMs, methods for producing such molecules, and ELAMs (including the specific molecules ELAM1 and VLAM1 and Ib) essentially free of normally associated animal proteins are disclosed. Antibodies to ELAMs are also disclosed. DNA sequences encoding molecules involved in leukocyte adhesion (MILAs), method for producing such molecules and MILAs (including the specific molecule, CDX) essentially free of normally associated animal proteins are also disclosed. Antibody preparations which are reactive for MILAs are also disclosed. Methods for identifying molecules which inhibit binding of leukocytes to endothelial cells, methods for inhibiting leukocyte binding to endothelial cells; and methods for detecting acute inflammation arty disclosed.
Benjamin Christopher D.
Goelz Susan E.
Hession Catherine A.
Lobb Roy R.
Osborn Laurelee
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Biogen Inc.
Biogen Idec Ma Inc.
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