C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01) C12N 5/02 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2480190
The invention is a population of embryonic endothelial cells produced in vitro from human embryonic stem cells. The cells produce platelet endothelial cell adhesion molecule-1 and are vasculogenic. The cells may be combined with a cell support substrate, seeded on a polymer matrix, or combined with a cell- support substrate that is infused into a polymer matrix. The cells may also be injected directly into a tissue site.
La présente invention concerne une population de cellules embryonnaires endothéliales produites in vitro à partir de cellules souches embryonnaires humaines. Ces cellules produisent la molécule d'adhésion 1 de cellules endothéliales présente sur les plaquettes et sont vasculogènes. Lesdites cellules peuvent être combinées à un substrat de support de cellules, semées sur une matrice polymère ou combinées à un substrat de support de cellules qui est introduit dans une matrice polymère. Ces cellules peuvent également être introduites directement dans un site tissulaire.
Amit Michal
Itskovitz-Eldor Joseph
Langer Robert S.
Levenberg Shulamit
Massachusetts Institute Of Technology
Robic
Technion Research And Development Foundation Ltd.
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