Endothelial cells derived from primate embryonic stem cells

Details Endothelial cells derived from primate embryonic stem cells Endothelial cells derived from primate embryonic stem cells

C - Chemistry, Metallurgy

12

N

C12N 5/071 (2010.01) C12N 5/0735 (2010.01) A61K 35/12 (2006.01)

Patent

CA 2465173

A method is described to induce primate embryonic stem cells to differentiate into a relatively homogenous population of endothelial cells. The ES derived endothelial cells have the general morphological and cell surface marker characteristics of endothelial cells. The ES derived endothelial cells also are capable of inducing and participating in blood vessel formation (or vascularization) when transplanted into tissue in vivo.

L'invention concerne un procédé consistant à activer la différenciation de cellules souches embryonnaires de primates en une population relativement homogène de cellules endothéliales. Les cellules endothéliales provenant de cellules souches présentent les caractéristiques morphologiques et de marquage de surface des cellules endothéliales. Ces cellules peuvent également induire la formation de vaisseaux sanguins (ou vascularisation) et y participer, lorsqu'elles sont transplantées dans un tissus in vivo.

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