Endothelial lining effects and treatment of vasospastic...

A - Human Necessities – 61 – K

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A61K 35/14 (2006.01) A61K 41/00 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2194485

Vasospastic disorders such as Raynaud's phenomenon are treated by administering to the patient an aliquot of autologous blood which has been subjected simultaneously to heat, ultraviolet irradiation and oxidative environment so as to render the blood aliquot capable of generating in the patient's bloodstream after administration a population of stimulated leukocytes having upregulated expression of CD25 cell surface markers, along with an enhancement of endothelial function in the patient.

Troubles vasospastiques tels que la maladie de Raynaud, traités par administration à un patient d'une fraction de sang autologue qui a été soumise simultanément à la chaleur, aux rayons ultraviolets et à un environnement oxydatif de sorte qu'elle soit capable de générer dans le flux sanguin du patient, après administration, une population de leucocytes stimulés présentant une expression régulée à la hausse des marqueurs de surface cellulaire CD25, ainsi que d'améliorer la fonction endothéliale dudit patient.

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