C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/19 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) C07K 1/36 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C12Q 1/02 (2006.01) G01N 33/48 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2172729
This invention provides a purified endothelial monocyte activating polypeptide (EMAP II). It further provides a method of obtaining purified endothelial monocyte activating polypeptide (EMAP II), a method of making antibodies to it and a method of detecting it. This invention also provides an effector cell activating protein which contains an amino acid sequence homologous to RIGRIVT and a method of detecting same. This invention also provides a method of treating a tumor in a subject by administering an effective dose of endothelial monocyte activating polypeptide (EMAP II).
L'invention porte sur un polypeptide purifié d'activation des monocytes endothéliaux (EMAPII) et sur sa méthode d'obtention ainsi que sur des méthodes d'obtention du polypeptide et de détection de ses anticorps. L'invention porte également sur une protéine d'activation des cellules effectrices qui contient une séquence aminoacide homologue du RIGRIVT, et sur sa méthode de détection. L'invention porte enfin sur une méthode de traitement d'une tumeur consistant à administrer au patient une dose efficace dudit polypeptide.
Clauss Matthias
Kao Janet
Kayton Mark
Libutti Steven K.
Stern David M.
Gowling Lafleur Henderson Llp
The Trustees Of Columbia University In The City Of New York
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