C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/19 (2006.01) A61K 31/70 (2006.01) A61K 38/19 (2006.01) A61K 48/00 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2221821
A human EMAP III polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating neoplasia. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
L'invention concerne un polypeptide, d'origine humaine, de type III, activateur des monocytes et des cellules endothéliales(EMAP III) ainsi que l'ADN (ARN) codant ce type de polypeptides. L'invention concerne également un mode opératoire de production d'un tel polypeptide par des techniques de recombinaison ainsi que des procédés d'utilisation d'un tel polypeptide aux fins de la prévention et/ou du traitement de la néoplasie. L'invention concerne en outre des procédés de diagnostic permettant d'une part, d'identifier des mutations dans la séquence d'acides nucléiques codant ce polypeptide et d'autre part, de déceler des modifications de la concentration de ce polypeptide associées à des maladies telles que le cancer.
Coleman Timothy A.
Olsen Henrik S.
Rosen Craig A.
Gowling Lafleur Henderson Llp
Human Genome Sciences Inc.
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