Endothelial progenitor cells and methods of use thereof

Details Endothelial progenitor cells and methods of use thereof Endothelial progenitor cells and methods of use thereof

C - Chemistry, Metallurgy

12

N

C12N 5/0789 (2010.01) C12N 5/071 (2010.01) A61K 35/12 (2006.01) A61K 35/14 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2559110

Endothelial progenitor cells immunoreactive for VEGFR-2 or Tie-2, and CD45 are provided. Optionally the cell is immunoreactive with CD14. The cells are capable of differentiating in vivo into an endothelial cell or a smooth muscle cells. The cultures integrate well after transplantation into adult vasculature.

L'invention porte sur des cellules endothéliales progénitrices immunoréactives vis à vis du VEGFR-2 ou Tie-2, du CD45 et facultativement du CD14. Lesdites cellules ont la capacité de se différencier <i>in vivo</i> en cellules endothéliales ou en cellules de muscles lisses, et leur culture s'intègre bien à la vasculature adulte après une transplantation.

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