Endotheliase-2 ligands

Details Endotheliase-2 ligands Endotheliase-2 ligands

C - Chemistry, Metallurgy

07

K

C07K 16/40 (2006.01) A61K 39/395 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2535859

This disclosure provides, inter alia, proteins that bind to ET2, e.g., immunoglobulins that inhibit ET2 with high affinity and selectivity. The ET2 binding proteins can be used to treat a variety of disorders including angiogenesis-associated disorders.

L'invention concerne notamment des protéines qui se lient à ET2, p.ex. des immunoglobulines qui inhibent ET2 avec une affinité et une sélectivité élevées. ces protéines de liaison de ET2 peuvent servir au traitement de divers troubles, notamment des troubles liés à l'angiogenèse.

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