A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/505 (2006.01)
Patent
CA 2578044
The invention relates generally to combination therapies comprising an endothelin A receptor (ETA) antagonist and a phosphodiesterase 5 (PDE5) inhibitor, pharmaceutical compositions comprising ETA antagonist and PDE5 inhibitor and methods of treating various disorders comprising administering an ETA antagonist and a PDE5 inhibitor. In particular, the combination therapies and pharmaceutical compositions are useful for the treatment and/or prevention of cardiac disorders such as pulmonary arterial hypertension (PAH).
L'invention concerne des polythérapies en général, comprenant un antagoniste du récepteur de l'endothéline A (ET<SB>A</SB>) et un inhibiteur de phosphodiestérase 5 (PDE5), des compositions pharmaceutiques contenant un antagoniste de ET<SB>A</SB> et un inhibiteur de PDE5 et des méthodes pour traiter divers troubles, ces méthodes consistant à administrer un antagoniste de ET<SB>A</SB> et un inhibiteur de PDE5. Les polythérapies et les compositions pharmaceutiques sont particulièrement utiles pour traiter et/ou prévenir des troubles cardiaques tels que l'hypertension artérielle pulmonaire (PAH).
Dixon Richard
Keyser Donald Jeffrey
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Encysive Pharmaceuticals
LandOfFree
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