Endothelin and endothelin receptor agonists in the treatment...

A - Human Necessities – 61 – K

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Details

A61K 38/22 (2006.01) A61K 38/04 (2006.01) A61K 38/16 (2006.01) A61P 3/00 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2646704

Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an endothelin or an endothelin agonist, alone or in conjunction with other compounds or compositions that affect satiety. The methods are useful for treating conditions or disorders, including obesity, Type II diabetes, eating disorders, and insulin-resistance syndrome. Pharmaceutical compositions for use in the methods of the invention are also disclosed.

La présente invention concerne des procédés permettant de traiter des affections ou des troubles qui peuvent être atténués en réduisant l'absorption d'aliments, lesdits procédés comprenant l'administration d'une quantité efficace d'une endothéline ou d'un agoniste de l'endothéline, seuls ou conjointement avec d'autres composés ou compositions qui ont un effet sur la satiété. Les procédés selon l'invention sont utiles pour traiter des affections ou des troubles, y compris l'obésité, le diabète de type II, les troubles de l'alimentation, et le syndrome d'insulino-résistance. L'invention concerne de plus des compositions pharmaceutiques destinées à être utilisées dans les procédés de l'invention.

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