Endothelin antagonistic peptide derivatives

Details Endothelin antagonistic peptide derivatives Endothelin antagonistic peptide derivatives

C - Chemistry, Metallurgy

07

K

C07K 5/02 (2006.01) A61K 38/04 (2006.01) C07K 5/04 (2006.01) C07K 5/06 (2006.01) C07K 5/083 (2006.01) C07K 5/103 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2043741

Disclosed is a peptide derivative of the formula: Image wherein A1, A2, R3, R4, R5, B and X2 are defined herein. Also disclosed is a drug for treating hypertension, pulmonary hypertension, Raynaud's disease, acute renal failure, myocardial infarction, angina pectoris, cerebral infarction, cerebral vasospasm, arteriosclerosis, asthma, endotoxin shock, endotoxin-induced multiple organ failure or disseminated intravascular coagulation, and/or cyclosporin-induced renal failure or hypertension, which drug is a peptide derivative of the formula (I) or a pharmaceutically-acceptable salt thereof.

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