Endothelin antagonists: n-[[2'-[...

C - Chemistry – Metallurgy – 07 – D

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C07D 413/14 (2006.01) A01N 43/76 (2006.01) A61K 31/42 (2006.01) C07D 263/08 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2279178

The compounds N-[[2'-[ [(4,5-dimethyl-3-isoxazolyl) amino]sulfonyl]-4-(2- oxazolyl) [1,1'-biphenyl]-2-yl]methyl]-N, 3,3-trimethylbutanamide and N-(4,5- dimethyl-3-isoxazolyl)-2'-[ (3,3-dimethyl-2-oxo-1-pyrrolidinyl) methyl]-4'-(2- oxazolyl) [1,1'-biphenyl]-2-sulfonamide, and salts thereof, useful as endothelin antagonists.

Les composés N-[[2'-[[4,5-diméthyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphényl]-2-yl]méthyl]-N,3,3-triméthylbutanamide et N-(4,5-diméthyl-3-isoxazolyl)-2'-[3,3-diméthyl-2-oxo-1-pyrrolidinyl)méthyl]-4'-(2-oxazolyl)[1,1'-biphényl]-2-sulfonamide, et leurs sels, sont utiles comme antagonistes de l'endothéline.

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