Endothelin-antagonizing peptide

Details Endothelin-antagonizing peptide Endothelin-antagonizing peptide

C - Chemistry, Metallurgy

12

P

C12P 21/02 (2006.01) C07K 5/113 (2006.01) C07K 5/117 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 7/50 (2006.01) C07K 14/36 (2006.01) C07K 14/575 (2006.01) C12N 1/20 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2104952

- 94 - ABSTRACT The present invention relates to an endothelin- antagonizing peptide represented by the following formula (I): Image (I) (wherein A represents Asn or Asp; B represents His or Lys; E represents Ala or Ser; G represents Ala or Pro; X represents X1-Gly or Image ; and Y represents hydroxy, lower alkoxy, amino, Image or Image group [wherein each of X1 and X3 represents hydrogen, benzyloxy- carbonyl, t-butyloxycarbonyl or 9-fluorenylmethyloxycarbonyl, or carbonyl-substituted or unsubstituted lower alkanoyl; each of X2 and Y2 represents hydrogen; Y1 represents hydroxy, lower alkoxy or amino; or X1 and Y1, or X2 and Y2 are combined together to form a single bond: as X1-Y1 or X2-Y2; and Z represents hydroxy, lower alkoxy, benzyloxy, benzhydryloxy, or a group Gly-Z1 (where Z1 represents hydroxy, lower alkoxy, benzyloxy or benzhydryloxy, or is combined with X1 to form a single bond as X1-Z1), A l a - Z' (where Z1 is as defined previously), V a l - Z' (where Z1 is as defined previously), T r p - Z' (where Z1 is as defined previously), T r P - G l y - Z' (where Z1 is as defined previously), T r P - A s n - T y r - T y r -T r p - Z' - 95 - (where Z1 is as defined previously), T r p - P h e - P h e - A s n - T y r - T y r - 7 H y t - Z ' (where Z1 is as defined previously, and 7Hyt represents 7- hydroxytryptophan), T r p - P l e - I l e - T r p - Z ' (where Z1 is as defined previously), T r p - V a l - T y r - P h e - W - H i s - L e u - A s p - I l e - I l e - T r p - Z ' (where Z1 is as defined previously, and W represents Ala, Ser or Cys), T r p - W - H i s - L e u - A s p - I l e - I l e - T r p - Z ' (where Z1 and W are as defined previously), T r p - V a l - T y r - T y r - W - H i s - L e u - A s p - I l e - I l e - T r p - Z' (where Z1 and W are as defined previously), T r p - L e u - T y r - P h e - W - H i s - G i n - A s p - I l e - I l e - T r p - Z ' (where Z1 and W are as defined previously), T r p - V a l - T y r - P h e - P h e - A s n - T y r - T y r - T r p - Z ' (where Z1 and W are as defined previously), T r p - P h e - P h e - A s n - T y r - T y r - W - H i s - L e u - A s p - I l e - I l e - T r p - Z ' (where Z1 and W are as defined previously), T r p - P h e - P h e - A s n - T y r - T y r - A s n - I l e - I l e - T r p - Z ' (where Z1 is as defined previously), or J - P h e - M - Q - T y r - R - T - Z ' (where J is Trp or a single bond, M is Phe or a single bond, Q is Asn or a single bond, R is Tyr or a single bond and T is T r p, A l a, P h e, T y r, T r p - T r p, A s n - T y r - T y r - T r p, - 96 - T r p - A s n - T y r - T y r - T r p, T r p - V a l - T y r - P h e - W - H i s - L e u - A s p - I l e - I l e - T r p (where W is as defined previously) or a single bond; not more than one of J, M, Q, R and T is a single bond at the same time; and Z1 is as defined previously)]}.

Affiliated with

Also associated with

Rating

Endothelin-antagonizing peptide does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Endothelin-antagonizing peptide, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Endothelin-antagonizing peptide will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1509935