Endothelin receptors in morphine withdrawal

Details Endothelin receptors in morphine withdrawal Endothelin receptors in morphine withdrawal

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61K 31/485 (2006.01)

Patent

CA 2641386

The present invention relates to compositions and methods for managing opioid tolerance and reducing opioid withdrawal. More specifically, the present invention provides for endothelin, endothelin receptors, and endothelin receptor antagonists and agonists as a means for managing G-protein activity in the context of opioid tolerance and withdrawal.

La présente invention porte sur des compositions et des méthodes permettant de gérer la tolérance aux opiacés et de réduire le sevrage des opiacés. Cette invention porte de manière plus spécifique sur l'endothéline, des récepteurs de l'endothéline et des antagonistes et agonistes des récepteurs de l'endothéine comme moyen de gérer l'activité de la protéine G dans le contexte de la tolérance aux opiacés et du sevrage des opiacés.

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