C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) A61F 2/10 (2006.01) A61L 27/60 (2006.01) C12N 15/18 (2006.01)
Patent
CA 2608712
The invention relates to an endothelized artificial matrix comprising a fibrin gel, which is a superproducer of proantiogenic factors. The inventive matrix comprises a fibrin gel containing embedded endothelial cells which have been transfected in vitro with at least one adenoviral vector containing the sequence encoding at least one proangiogenic factor, which is inserted such that it can be overexpressed in said endothelial cells. The insertion of the aforementioned matrix between a flap and the receptor site thereof during a transplant procedure improves the survival rates of said flap, since the endothelized matrix can induce angiogenesis both in the flap and in the receptor site and, in this way, improve the vascularization of the transplanted area.
La présente invention concerne une matrice artificielle de gel de fibrine envahie de cellules endothéliales superproductrices de facteurs pro-angiogéniques. Cette matrice comprend un gel de fibrine dans lequel sont noyées des cellules endothéliales transfectées in vitro par au moins un vecteur adénoviral contenant la séquence codante d'au moins un facteur pro-angiogénique introduite de façon à pouvoir être surexprimée dans lesdites cellules endothéliales. L'introduction de ladite matrice entre un lambeau et le milieu récepteur dans un processus de transplantation permet d'augmenter les chances de survie dudit lambeau, car la matrice envahie de cellules endothéliales est capable d'induire l'angiogenèse tant au niveau du lambeau que du milieu récepteur et d'améliorer ainsi la vascularisation de la zone de transplantation.
Lasso Vazquez Jose Maria
Nava Perez Paola
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Fundacion Para La Investigacion Biomedica Del Hospital Gregorio
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