Endowing cells with antibody specificity

Details Endowing cells with antibody specificity Endowing cells with antibody specificity

C - Chemistry, Metallurgy

12

N

167/104, 167/114

C12N 15/85 (2006.01) A61K 35/18 (2006.01) A61K 48/00 (2006.01) C07K 14/725 (2006.01) C07K 16/44 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12N 15/62 (2006.01)

Patent

CA 1338570

There are produced recombinant gene pairs which endow mononuclear cells, mainly various lymphocyte type cells, with antibody-type specificity. In specific gene pairs the rearranged gene pairs code for a binding site of an antibdoy molecule from the same species, of the T-cell receptor gene, or another species. Gene pairs of the invention code, for example for antibodies specific towards tumor-specific antigens, viral antigens, modified self antigens, bacterial or fungal antigens, autoimmune type disease antigens and the like. The invention further relates to expression vectors for the effective transfection of such cell types comprising such a recombinant gene pair, to methods for producing same and to pharmaceutical compositions comprising as active ingredient an effective quantity of lymphocytes transfected with such gene pairs.

598635

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