Endoxifen methods and compositions in the treatment of...

A - Human Necessities – 61 – K

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A61K 31/138 (2006.01) A61K 9/127 (2006.01)

Patent

CA 2757838

The present invention provides compositions containing endoxifen, formulations and liposomes of endoxifen, methods of prepara-tion of such agents and formulations, and use of such agents and formulations for the treatment of a subject having or at risk for psychiatric and neu-rodegenerative diseases, infectious diseases, fertil-ity disorders, osteoporosis, osteoarthritis, and/or cardiovascular diseases. Specifically, the present invention relates to compositions comprising en-doxifen for use in the treatment of such disorders or predisposition to such disorders, for use in manufacture of medicaments for treating such dis-orders, and methods comprising use of such com-positions in such treatments.

Cette invention concerne des compositions contenant de l'endoxifène, des formulations et des liposomes d'endoxifène, des procédés de préparation de ces agents et formulations, et l'utilisation de ces agents et formulations pour traiter un sujet ayant ou risquant de développer des maladies psychiatriques et neurodégénératives, des maladies infectieuses, des troubles de la fertilité, une ostéoporose, une arthrose, et/ou des maladies cardiovasculaires. Plus spécifiquement, cette invention concerne des compositions contenant de l'endoxifène destinées à être utilisées pour traiter ces troubles ou une prédisposition auxdits troubles, pour fabriquer des médicaments destinés à traiter ces troubles, et des procédés comprenant l'utilisation desdites compositions dans ces traitements.

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