Endozepine-like polypeptides and polynucleotides encoding same

C - Chemistry – Metallurgy – 12 – N

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2386199

Disclosed herein are human nucleic acid sequences which encode endozepine-like polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies which immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving this novel human endozepine-like nucleic acid and protein.

La présente invention concerne de nouvelles séquences d'acide nucléique d'origine humaine qui codent des polypeptides de type endozépine ; des polypeptides codés par ces séquences d'acide nucléique et des anticorps qui se lient de manière immunospécifique au polypeptide, ainsi que des dérivés, des variants, des mutants ou des fragments dudit polypeptide, dudit polynucléotide ou dudit anticorps. On décrit également des procédés de thérapie, de diagnostic et de recherche permettant de diagnostiquer, traiter et prévenir des maladies associées à ce nouvel acide nucléique de type endozépine et à la protéine d'origine humaine.

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