C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/08 (2006.01) A61K 31/47 (2006.01) A61K 47/48 (2006.01)
Patent
CA 2229269
The present invention provides compounds of formulae (I) and (II), where X in formula (I) represents a group cleavable by a nitroreductase or carboxypeptidase enzyme. Enzymatic activation of the compounds provide pharmaceutical compounds which may be used for the treatment of neoplastic disease.
La présente invention se rapporte à des composés représentés par les formules (I) et (II), X représentant, dans la formule (I), un groupe clivable par un enzyme de type nitroréductase ou carboxypeptidase. L'activation enzymatique de ces composés produit des composés pharmaceutiques qui peuvent servir au traitement de maladies néoplasiques.
Denny William Alexander
Hay Michael Patrick
Wilson William Robert
Auckland Uniservices Limited
Denny William Alexander
Hay Michael Patrick
Kirby Eades Gale Baker
Wilson William Robert
LandOfFree
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