Enema preparations and their use

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/00 (2006.01) A61K 41/00 (2006.01) A61K 47/10 (2006.01) A61K 47/12 (2006.01) A61K 47/14 (2006.01) A61K 47/18 (2006.01) A61K 47/20 (2006.01) A61K 47/34 (2006.01) A61K 47/38 (2006.01)

Patent

CA 2748155

This invention relates to improved methods of photodynamic treatment and diagnosis of cancer and non-cancerous conditions, and in particular to improved enema preparations for use in such methods, said enema preparations comprising a photosensitiser which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative thereof, e.g. a 5-ALA ester. Such preparations may further comprise one or more viscosity enhancing agents, mucoadhesive or mucolytic agents, penetration enhancers or chelating agents. The methods and preparations herein described are particularly suitable for use in photodynamic methods of treating and/or diagnosing cancer and non-cancerous conditions in the colon and/or rectum.

La présente invention concerne des procédés améliorés de traitement et de diagnostic photodynamique du cancer et d'affections non cancéreuses, et en particulier des préparations de lavement améliorées pour utilisation dans de tels procédés, lesdites préparations de lavement comprenant un photosensibilisateur qui est l'acide 5-aminolévulinique (5-ALA) ou un précurseur ou dérivé de celui-ci, par exemple un ester de 5-ALA. De telles préparations peuvent comprendre en outre un ou plusieurs agents d'amélioration de la viscosité, des agents mucoadhésifs ou mucolytiques, des agents de pénétration ou des agents chélateurs. Les procédés et préparations présentement décrits sont particulièrement adaptés pour utilisation dans des procédés photodynamiques de traitement et/ou de diagnostic du cancer et d'affections non cancéreuses dans le côlon et/ou le rectum.

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